Issue 13, 1985
From the journal:

Journal of the Chemical Society, Chemical Communications

Synthesis of (11S)- and (11R)-[11-2H1]porphobilinogen; stereochemical studies on hydroxymethylbilane synthase (PBG deaminase)

Werner Neidhart,   Paul C. Anderson,   Graham J. Hart  and  Alan R. Battersby  

Abstract

(11S)-and (11R)-[11-2H1]Porphobilinogen (PBG) are synthesized and their configurations are established by degradation to a derivative of 2H1-glycine; they are used to prove that when hydroxymethylbilane synthase (PBG deaminase) acts on PBG in the presence of ammonia, aminomethylbilane is formed with overall retention of configuration at the NH2CHD-group.

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Article information

DOI
https://doi.org/10.1039/C39850000924
Article type
Paper

J. Chem. Soc., Chem. Commun., 1985, 924-927

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Synthesis of (11S)- and (11R)-[11-2H1]porphobilinogen; stereochemical studies on hydroxymethylbilane synthase (PBG deaminase)

W. Neidhart, P. C. Anderson, G. J. Hart and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1985, 924 DOI: 10.1039/C39850000924

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