Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]

Bernard T. Golding; Anthony J. Smith

doi:10.1039/C39800000702

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Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]

Bernard T. Golding and Anthony J. Smith

Abstract

A stereoselective synthesis of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid (2a) from ethyl 8-oxo-1-azabicyclo[4.2.0]octane-7-carboxylate (4a) is described.

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DOI: https://doi.org/10.1039/C39800000702
Article type: Paper

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J. Chem. Soc., Chem. Commun., 1980, 702-703

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Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]

B. T. Golding and A. J. Smith, J. Chem. Soc., Chem. Commun., 1980, 702 DOI: 10.1039/C39800000702

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Journal of the Chemical Society, Chemical Communications

Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]

Abstract

Article information

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Synthesis via a bicyclic β-lactam of (αS,2R/αR,2S)-α-aminopiperidine-2-acetic acid, an amino-acid related to the anti-tumour agent ‘593A’[3,6-bis-(5-chloro-2-piperidyl)piperazine-2,5-dione]

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