Issue 12, 2017
From the journal:

Biomaterials Science

Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles†

Xiaoying Xu,‡a   Lingzhou Zhao,‡b   Xin Li,a   Peng Wang,a   Jinhua Zhao,*b   Xiangyang Shi ORCID logo *ac  and  Mingwu Shen*a  

* Corresponding authors

a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: mwshen@dhu.edu.cn, xshi@dhu.edu.cn

b Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China
E-mail: zhaojinhua1963@126.com

c CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal

Abstract

Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine–glycine–aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.

Graphical abstract: Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C7BM00826K
Article type
Communication
Submitted
08 Sep 2017
Accepted
29 Sep 2017
First published
03 Oct 2017

Biomater. Sci., 2017,5, 2393-2397

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Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles

X. Xu, L. Zhao, X. Li, P. Wang, J. Zhao, X. Shi and M. Shen, Biomater. Sci., 2017, 5, 2393 DOI: 10.1039/C7BM00826K

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