Issue 5, 2015
From the journal:

Biomaterials Science

Structural and functional changes in high-density lipoprotein induced by chemical modification†

Tatsuya Murakami,*a   Haruki Okamotoa  and  Hyungjin Kima  

* Corresponding authors

a Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: murakami@icems.kyoto-u.ac.jp

Abstract

Reconstituted high-density lipoprotein (rHDL), a natural nanoparticle consisting of apolipoprotein A-I and phospholipids, was modified with a hydrophobic fluorescent dye before (pre-rHDL) and after (post-rHDL) reconstitution. Pre-rHDL particles had a similar size to unmodified rHDL, but post-rHDL particles were significantly larger and their avidity for a HDL receptor was 2.6 times of that shown by pre-rHDL.

Graphical abstract: Structural and functional changes in high-density lipoprotein induced by chemical modification

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Article information

DOI
https://doi.org/10.1039/C4BM00402G
Article type
Communication
Submitted
21 Nov 2014
Accepted
17 Feb 2015
First published
05 Mar 2015
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2015,3, 712-715

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Structural and functional changes in high-density lipoprotein induced by chemical modification

T. Murakami, H. Okamoto and H. Kim, Biomater. Sci., 2015, 3, 712 DOI: 10.1039/C4BM00402G

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