Issue 32, 2017

Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

Abstract

A method for performing rapid, highly portable immunoassays at low limits of detection (LoD) has been developed by combining solid-phase microextraction membranes, gold nanoparticle labels, and surface-enhanced Raman scattering. The capability of this methodology is demonstrated through measurements of alphafetoprotein, a marker used to screen individuals for hepatocellular carcinoma, directly from human serum at an estimated LoD of 3 pg mL−1 in ∼2 min.

Graphical abstract: Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

Supplementary files

Article information

Article type
Communication
Submitted
10 Jul 2017
Accepted
31 Jul 2017
First published
09 Aug 2017

Anal. Methods, 2017,9, 4641-4646

Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

J. H. Granger, A. Skuratovsky, M. D. Porter, Courtney L. Scaife, J. E. Shea, Q. Li and S. Wang, Anal. Methods, 2017, 9, 4641 DOI: 10.1039/C7AY01689A

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