Issue 47, 2016
From the journal:

Analytical Methods

Hairpin DNA-fueled dynamic self-assembly of three-arm DNA branched junctions consisting of active DNAzyme structures for enzyme-free ultrasensitive detection of nucleic acids†

Ke Yang,*a   Ming Zeng,a   Xing He,c   Jianming Li*a  and  Dinggeng He*bc  

* Corresponding authors

a Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Human Anatomy, Histology and Embryology, Changsha Medical University, Changsha, China
E-mail: hedinggeng@hnu.edu.cn, yangkenhm@163.com, ljming0901@sina.com

b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

c College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Abstract

A novel enzyme-free dual signal amplification strategy based on programmable molecular hairpins has been developed for the ultrasensitive amplified detection of DNA via hairpin DNA-fueled dynamic self-assembly of three-arm DNA branched junctions consisting of active DNAzyme structures on each branch end.

Graphical abstract: Hairpin DNA-fueled dynamic self-assembly of three-arm DNA branched junctions consisting of active DNAzyme structures for enzyme-free ultrasensitive detection of nucleic acids

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Article information

DOI
https://doi.org/10.1039/C6AY02892F
Article type
Communication
Submitted
21 Oct 2016
Accepted
01 Nov 2016
First published
01 Nov 2016

Anal. Methods, 2016,8, 8262-8265

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Hairpin DNA-fueled dynamic self-assembly of three-arm DNA branched junctions consisting of active DNAzyme structures for enzyme-free ultrasensitive detection of nucleic acids

K. Yang, M. Zeng, X. He, J. Li and D. He, Anal. Methods, 2016, 8, 8262 DOI: 10.1039/C6AY02892F

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