Exploration of a β-cyclodextrin clicked chiral stationary phase in high-performance liquid chromatography

Abstract

The baseline enantioseparation of 19 racemic drugs including ondansetron, citalopram, galanthamine base, pregabalin, timolol, atenolol, tropicamide, ephedrine hydrochloride, flavanoids and aryl alcohols has been successfully achieved with a cyclodextrin clicked chiral stationary phase in high performance liquid chromatography. The best separation results were presented under optimized conditions. The effect of organic modifiers including methanol and acetonitrile on the enantioseparation of racemates was also studied. Chiral resolutions of 4.19 and 4.42 were achieved for citalopram and tropicamide, respectively.