Issue 23, 2017

Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells

Abstract

Herein, we present an overview of recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells. First, we discuss probe devices: a general outline, evaluation of O2 consumption, enzyme-modified electrodes, evaluation of endogenous enzyme activity, and the collection of cell components from cell aggregates are discussed. The next section is focused on integrated chip devices: a general outline, electrode array devices, smart electrode array devices, droplet detection of 3D cultured cells, cell manipulation using dielectrophoresis (DEP), and electrodeposited hydrogels used for fabrication of 3D cultured cells on chip devices are discussed. Finally, we provide a summary and discussion of future directions of research in this field.

Graphical abstract: Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells

Article information

Article type
Minireview
Submitted
31 Aug 2017
Accepted
21 Oct 2017
First published
26 Oct 2017
This article is Open Access
Creative Commons BY license

Analyst, 2017,142, 4343-4354

Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells

K. Ino, M. Şen, H. Shiku and T. Matsue, Analyst, 2017, 142, 4343 DOI: 10.1039/C7AN01442B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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