Issue 19, 2017

Raman endoscopy for monitoring the anticancer drug treatment of colorectal tumors in live mice

Abstract

A miniaturized Raman endoscope (mRE) system was employed to study the effects of anticancer treatment on colorectal tumors in a live murine model. The endoscope is narrow enough to observe the inside of the mouse colon under anesthesia. It has a channel for a ball lens mounted on a hollow fiber Raman probe (BHRP) to measure any targeted point under the visual control of the endoscope. Colorectal cancer tissue was observed to study the alterations of the tissue in response to anticancer drug treatment. Three anticancer drugs, 5-fluorouracil (5-FU), cisplatin (CDDP), and docetaxel, were employed. Although no alteration was recognized in the endoscopic visual observations at 2 weeks after the drug treatment, the Raman spectra obtained in the live mouse colon indicated that molecular changes of lipids and proteins were observed. This study demonstrates that in situ Raman analysis is highly sensitive for detecting the effects of anticancer drugs.

Graphical abstract: Raman endoscopy for monitoring the anticancer drug treatment of colorectal tumors in live mice

Supplementary files

Article information

Article type
Paper
Submitted
01 May 2017
Accepted
04 Aug 2017
First published
07 Aug 2017

Analyst, 2017,142, 3680-3688

Raman endoscopy for monitoring the anticancer drug treatment of colorectal tumors in live mice

A. Taketani, B. B. Andriana, H. Matsuyoshi and H. Sato, Analyst, 2017, 142, 3680 DOI: 10.1039/C7AN00720E

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