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Issue 10, 2017
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Solid-state nanopore analysis of alcohol-soluble molecules

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Abstract

We report on a modified solid-state nanopore measurement scheme to probe alcohol-soluble proteins. Taking advantage of the intrinsic alcohol solubility of LiCl as an electrolyte, we show that the devices can be operated in azeotropic mixtures of ethanol and water. We first characterize nanopore conductivity across a range of ethanol content as a function of both nanopore diameter and salt concentration, showing ionic response that can be understood through established models. Then, as a demonstration of resistive-pulse sensing, we measure and interpret electrical translocations of zeins, a class of alcohol-soluble maize protein.

Graphical abstract: Solid-state nanopore analysis of alcohol-soluble molecules

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Publication details

The article was received on 04 Jan 2017, accepted on 21 Apr 2017 and first published on 27 Apr 2017


Article type: Communication
DOI: 10.1039/C7AN00022G
Citation: Analyst, 2017,142, 1676-1681
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    Solid-state nanopore analysis of alcohol-soluble molecules

    D. B. Roy and A. R. Hall, Analyst, 2017, 142, 1676
    DOI: 10.1039/C7AN00022G

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