Issue 21, 2014
From the journal:

Analyst

Acoustic monitoring of changes in well-defined hyaluronan layers exposed to chondrocytes†

E. Nilebäck,ab   L. Enochson,c   N. Altgärde,a   M. Schnabelrauch,d   A. Lindahl,c   S. Svedhem*a  and  A. Kunze*ae  

* Corresponding authors

a Dept. of Appl. Physics, Chalmers University of Technology, Göteborg, Sweden
E-mail: sofia.svedhem@chalmers.se

b Biolin Scientific AB, Västra Frölunda, Sweden

c Dept. of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

d Biomaterials Department, INNOVENT e.V., 07745 Jena, Germany

e Inst. of Physical Chemistry, Univerisity of Götttingen, Göttingen, Germany
E-mail: angelika.kunze@chemie.uni-goettingen.de

Abstract

The interaction of human-derived chondrocytes and thin hyaluronan layers was studied using the quartz crystal microbalance with dissipation (QCM-D) technique combined with light microscopy. This approach allowed unique real-time monitoring of the interface between the cells and the sensor surface. Our results suggest that the hyaluronan layer is rapidly degraded by chondrocytes.

Graphical abstract: Acoustic monitoring of changes in well-defined hyaluronan layers exposed to chondrocytes

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Article information

DOI
https://doi.org/10.1039/C4AN01393J
Article type
Communication
Submitted
29 Jul 2014
Accepted
25 Aug 2014
First published
26 Aug 2014
This article is Open Access
Creative Commons BY license

Analyst, 2014,139, 5350-5353

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Acoustic monitoring of changes in well-defined hyaluronan layers exposed to chondrocytes

E. Nilebäck, L. Enochson, N. Altgärde, M. Schnabelrauch, A. Lindahl, S. Svedhem and A. Kunze, Analyst, 2014, 139, 5350 DOI: 10.1039/C4AN01393J

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