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Issue 11, 2010
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Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging

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Abstract

Ever since the advent of surface plasmon resonance (SPR) and SPR imaging (SPRi) in the early 1990s, their use in biomolecular interaction analysis (BIA) has expanded phenomenally. An important research area in SPR sensor development is the design of novel and effective interfaces that allow for the probing of a variety of chemical and biological interactions in a highly selective and sensitive manner. A well-designed and robust interface is a necessity to obtain both accurate and pertinent biological information. This review covers the recent research efforts in this area with a specific focus towards biointerfaces, new materials for SPR biosensing, and novel array designs for SPR imaging. Perspectives on the challenges ahead and next steps for SPR technology are discussed.

Graphical abstract: Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging

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Publication details

The article was received on 02 Jul 2010, accepted on 10 Aug 2010 and first published on 07 Sep 2010


Article type: Minireview
DOI: 10.1039/C0AN00466A
Citation: Analyst, 2010,135, 2759-2767
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    Interface design and multiplexed analysis with surface plasmon resonance (SPR) spectroscopy and SPR imaging

    M. J. Linman, A. Abbas and Q. Cheng, Analyst, 2010, 135, 2759
    DOI: 10.1039/C0AN00466A

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