BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu2+ in living cells

Hye Young Lee; Hyunjong Son; Jung Mi Lim; Jungmin Oh; Dongmin Kang; Won Seok Han; Jong Hwa Jung

doi:10.1039/C0AN00129E

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BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu²⁺ in living cells†

Hye Young Lee,^a Hyunjong Son,^a Jung Mi Lim,^b Jungmin Oh,^c Dongmin Kang,*^b Won Seok Han*^a and Jong Hwa Jung*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, S. Korea
E-mail: jonghwa@gnu.ac.kr

^b Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, S. Korea

^c Chuncheon Center, Korea Basic Science Institute, Chuncheon 200-701, S. Korea

Abstract

A new fluoro-chromogenic chemosensor based on BODIPY-functionalized gold nanoparticles 1 is prepared. Addition of Cu²⁺ ions to aqueous solutions of 1 gave an instantaneous color change along with a blue-shift of the absorption band and quenching of the emission spectrum at room temperature. The chemosensor 1 exhibits a high affinity and selectivity for Cu²⁺ over competing metal ions tested. Moreover, confocal microscopy experiments establish that 1 can be used for detecting Cu²⁺ levels within living cells.

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Article information

DOI: https://doi.org/10.1039/C0AN00129E
Article type: Paper
Submitted: 10 Mar 2010
Accepted: 20 May 2010
First published: 23 Jun 2010

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Analyst, 2010,135, 2022-2027

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BODIPY-functionalized gold nanoparticles as a selective fluoro-chromogenic chemosensor for imaging Cu²⁺ in living cells

H. Y. Lee, H. Son, J. M. Lim, J. Oh, D. Kang, W. S. Han and J. H. Jung, Analyst, 2010, 135, 2022 DOI: 10.1039/C0AN00129E

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