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Issue 7, 2010
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Visual detection of ascorbic acid via alkyneazide click reaction using gold nanoparticles as a colorimetric probe

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Abstract

An approach for visual sensing of ascorbic acid is presented. This method is based on the distance-dependent optical property of gold nanoparticles and the Cu+-catalyzed alkyneazide click reaction. We prepared the terminal azide- and alkyne-functionalized gold nanoparticle probes. In the presence of Cu2+, ascorbic acid could rapidly induce the aggregation of the functionalized gold nanoparticles, thereby resulting in a red-to-purple (or pink) color change. Ascorbic acid can be quantified visually or using a UV-vis spectrometer. The present limit of detection for ascorbic acid is 3 nM. This method exhibits excellent selectivity over other common organic reducing compounds (such as glucose, cysteine, dopamine, thiamine and uric acid). Without the aid of any advanced instruments, the assay of ascorbic acid could be performed with one step at room temperature. This method provides a potentially useful tool for the on-site detection of ascorbic acid.

Graphical abstract: Visual detection of ascorbic acid via alkyne–azide click reaction using gold nanoparticles as a colorimetric probe

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Publication details

The article was received on 02 Feb 2010, accepted on 29 Mar 2010 and first published on 30 Apr 2010


Article type: Paper
DOI: 10.1039/C0AN00056F
Citation: Analyst, 2010,135, 1579-1584
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    Visual detection of ascorbic acid via alkyneazide click reaction using gold nanoparticles as a colorimetric probe

    Y. Zhang, B. Li and C. Xu, Analyst, 2010, 135, 1579
    DOI: 10.1039/C0AN00056F

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