Linker immobilization of protein and oligonucleotide on indium-tin-oxide for detection of probe–target interactions by Kelvin physics

Abstract

This work describes a label-free microarray analysis technique capable of detecting biomolecule target interactions with probes being anchored with a new linker-diluent system on indium-tin-oxide. The method is based on the differential work function characteristics of the substrate measured by a scanning Kelvin nanoprobe in terms of contact potential difference signals.