Issue 5, 2009
From the journal:

Analyst

Design of liposome-based pH sensitive nanoSPINprobes: nano-sized particles with incorporated nitroxides

Yakov Y. Woldman,ac   Sergey V. Semenov,ab   Andrey A. Bobko,a   Igor A. Kirilyuk,d   Julya F. Polienko,d   Maxim A. Voinov,e   Elena G. Bagryanskayab  and  Valery V. Khramtsov*a  

* Corresponding authors

a The Ohio State University Medical Center, Columbus, USA
E-mail: valery.khramtsov@osumc.edu
Fax: +1 (614) 293-4799
Tel: +1 (614) 688-3664

b International Tomography Center SB RAS, Novosibirsk, Russia

c Valdosta State University, Valdosta, GA, USA

d Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia

e North Carolina State University, Department of Chemistry, Raleigh, NC, USA

Abstract

Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H+, while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction.

Graphical abstract: Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides

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Article information

DOI
https://doi.org/10.1039/B818184E
Article type
Paper
Submitted
30 Oct 2008
Accepted
25 Feb 2009
First published
11 Mar 2009

Analyst, 2009,134, 904-910

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Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides

Y. Y. Woldman, S. V. Semenov, A. A. Bobko, I. A. Kirilyuk, J. F. Polienko, M. A. Voinov, E. G. Bagryanskaya and V. V. Khramtsov, Analyst, 2009, 134, 904 DOI: 10.1039/B818184E

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