Issue 7, 2005

Paracetamol voltammetric microsensors based on electrocopolymerized–molecularly imprinted film modified carbon fiber microelectrodes

Abstract

A molecularly imprinted polymer is presented as a carbon fiber microelectrode coating for determining the presence of paracetamol. The polymeric film was obtained by electrocopolymerization of o-phenylenediamine and aniline in the presence of the template molecule, through the use of cyclic voltammetry. After removing the template, the signals of the microsensor were converted into physical ones by a voltammetric transductor using square wave voltammetry. Various parameters influencing the electropolymerization and voltammetric determination processes were examined and optimized. The response of the imprinted microsensor to paracetamol was linearly proportional to its concentration over the range 6.5 × 10−6 to 2.0 × 10−3 mol l−1, with good stability and reproducibility (RSD < 5.6%). The detection limit was 1.5 µM. Under the experimental conditions used the voltammetric microsensor was able to differentiate between paracetamol and other closely structurally-related compounds present in biological fluids, such as certain catecholamines.

Graphical abstract: Paracetamol voltammetric microsensors based on electrocopolymerized–molecularly imprinted film modified carbon fiber microelectrodes

Article information

Article type
Paper
Submitted
24 Feb 2005
Accepted
25 Apr 2005
First published
17 May 2005

Analyst, 2005,130, 1012-1018

Paracetamol voltammetric microsensors based on electrocopolymerized–molecularly imprinted film modified carbon fiber microelectrodes

A. Gómez-Caballero, M. A. Goicolea and R. J. Barrio, Analyst, 2005, 130, 1012 DOI: 10.1039/B502827B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements