Batch and flow injection spectrophotometric determination of aztreonam

Abstract

A method for the spectrophotometric determination of aztreonam operating manually and by flow injection is reported. The method is based on the reaction with hydroxylamine to form hydroxamic acid and subsequent reaction with Fe^III, giving a red complex. The effect of the concentrations of the reagents was studied and the reaction conditions are discussed. Nickel(II) was used as a catalyst. The method was applied to the determination of aztreonam in pharmaceutical products.