Propargyl polyamines (putrescine, spermidine, and spermine) were synthesized and evaluated as minimal-tag analogs for high-resolution intracellular imaging in mammalian cells and zebrafish. These compounds reveal structure-dependent differences in subcellular distribution with unprecedented resolution, discriminating among closely related polyamines.
Z. Sas, M. Zakrzewski, W. Czestkowski, P. Wanat, A. Wardak, J. Zmorzynska, A. Marusiak and R. Serwa, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06304C
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