An AIE-Active Platinum Complex for Enhanced Photodynamic Therapy

Abstract

Conventional photodynamic therapy (PDT) suffers from suffer aggregation-caused quenching and high oxygen dependence. Herein, we report a platinum (Pt)-coordinated photosensitizer (TPAQPt) for hypoxia-tolerant PDT. Inheriting aggregation-induced emission (AIE) feature, high spin orbital coupling and intramolecular transfer ability, TPAQPt exhibits robust type I reactive oxygen species generation and promising antitumor PDT effect.

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Article information

Article type
Communication
Submitted
16 Sep 2025
Accepted
11 Dec 2025
First published
12 Dec 2025

Chem. Commun., 2026, Accepted Manuscript

An AIE-Active Platinum Complex for Enhanced Photodynamic Therapy

P. Liang, W. Li, B. Z. Tang and G. Feng, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC05324B

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