Palladium-Catalyzed Amidocarbonylation of Thioethers: Access to α-Amide-Substituted Thioether Derivatives

Abstract

Thioethers play a crucial role as structural components in a wide range of natural products, pharmaceuticals, and industrial materials, influencing their chemical characteristics and biological functions. Herein, we report a palladium-catalyzed aminocarbonylation reaction of thioethers with amines as the nucleophiles. This palladium-catalyzed carbonylation reaction features a wide substrate scope and functional group tolerance, enabling the efficient C(sp 3 )-H aminocarbonylation of thioethers to afford the corresponding amides in good yields.