Helicoselective assembly of 2-pyranone-helicenoids via NHC-catalyzed [3 + 3] annulation

Abstract

Helical frameworks play a vital role in supramolecular chemistry and materials sciences. Nevertheless, the scarcity of robust stereoselective methodologies continues to impede their practical development. We herein report an NHC-catalyzed helicoselective [3 + 3] annulation approach for the assembly of chiral 2-pyranone fused helicenoids. This protocol enables the conversion of achiral starting materials into chiral 2-pyranone-helicenoids with good to high yields and high to excellent enantioselectivities.