Recent advances in chemoenzymatic synthesis of oligosaccharides and polysaccharides

Abstract

Chemoenzymatic methods are essential tools for synthesising a wide range of saccharides and their derivatives, including oligosaccharides, polysaccharides, and glycoconjugates, in the fields of glycotechnology and polymer chemistry. This review summarises recent progress and provides an overview of research on chemoenzymatic synthesis of oligosaccharides and polysaccharides through the combined use of chemical and enzymatic reactions. The methodologies are discussed separately for each class of enzyme: glycosyltransferases, glycan phosphorylases, and glycosyl hydrolases.