Advances in chiral analysis: from classical methods to emerging technologies

Abstract

The wide impact that chirality exerts in various fields of science has continuously pushed the development of methods and instruments capable of performing fast and reliable enantiomeric excess (ee) determination. From the historical optical polarimeter to modern instruments and supramolecular probes, this research field is continuously developing with the purpose of finding techniques of more general applicability and/or reducing the time and cost of analysis. The aim of this tutorial review is to provide the reader with a comprehensive overview of the available methodologies, referring to more specific reviews on the topic when available. Particular focus will be directed towards recent progress in this field, highlighting the advantages and disadvantages of the techniques and indicating recent trends in research.