Ag(I)-Mediated Mono-selective C(sp2)─H Chalcogenation of α-Aminotropones and Their Peptides at Room Temperature

Abstract

This report describes an Ag(I)-mediated strategy for the mono-selective chalcogenation of α-aminotropones and their peptides with a range of disulfides and diselenides at ambient temperature. The method efficiently furnishes mono-chalcogenated aminotropone derivatives in moderate to good yields, while demonstrating compatibility with diverse substrates and functional groups, offering synthetic versatility in downstream applications.