Peptide-Based Aggregation-Induced Emission Fluorescent Probe for Rapid and Accurate Detection of Low Molecular Weight Heparin

Abstract

Monitoring low molecular weight heparin (LMWH) is essential in clinical practice. We present a peptide-based aggregation-induced emission fluorescent probe, Z-BTDPA-Pep, capable of rapid, sensitive, and selective detection of LMWH in serum (0.1–2.0 U/ml, LOD = 0.00378 U/ml). The results correlate well with the clinical gold-standard anti-Xa assay, highlighting its potential for real-time LMWH monitoring and safer clinical drug administration.