We developed a novel bivalent albumin binder composed of two lysine-(p-iodophenyl)butyric acid, (Lys-IPBA)2, which markedly enhanced tumor retention of a FAP-targeted radioligand compared to Lys-IPBA. The results suggest the promising property of (Lys-IPBA)2 as a pharmacokinetic modifier of radioligands for cancer diagnosis and therapy.
K. Nakashima, K. Yamaguchi, K. Saito, H. Watanabe and M. Ono, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC05231A
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