We describe a molybdenum-catalyzed deoxygenative annulation of 2-aminobenzophenones and aldehydes to access 2,3-disubstituted indoles. The readily available substrates showed good functional group tolerance, and the gram-scale indole preparation could be achieved. A mechanism involving imine condensation and Mo-carbene insertion into C(sp2)-H bond has been proposed.
H. Chu, X. Lv, Y. Luo, M. Liu, R. Huang, X. Q. Feng and F. Chen, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC05181A
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