Calcium Catalysed Strecker-Type Reactions Towards α-Aminonitriles

Abstract

We report an operationally simple calcium catalysed Strecker type reaction for the synthesis of a-aminonitriles from readily available N,O-acetals. The reaction is tolerant to a wide range of useful functional groups, including heterocycles, and provides the product in good to excellent yields. Additionally, the reaction does not require the need for anhydrous or air-free conditions, making it a suitable candidate for high throughput experimentation.

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Article information

Article type
Communication
Submitted
28 Jan 2025
Accepted
14 Mar 2025
First published
14 Mar 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Accepted Manuscript

Calcium Catalysed Strecker-Type Reactions Towards α-Aminonitriles

A. J. Basson, M. P. Cameron and M. G. McLaughlin, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC00539F

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