Harnessing Nitroarenes: Photo-Driven Synergistic Construction of Phosphinic Amides via Hydrogen Transfer and Oxygen Migration

Abstract

A photo-mediated cascade rearrangement of nitroarenes in an electron donor-acceptor (EDA) complex generates phosphinic amides without metal or oxidants. Utilizing oxygen atoms from nitro groups, the reaction facilitates P(III) to P(V) conversion. The method shows broad substrate scope and compatibility with late-stage functionalization, offering potential for pharmaceutical synthesis.

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2025
Accepted
11 Mar 2025
First published
12 Mar 2025

Chem. Commun., 2025, Accepted Manuscript

Harnessing Nitroarenes: Photo-Driven Synergistic Construction of Phosphinic Amides via Hydrogen Transfer and Oxygen Migration

B. Sun, Z. Zhang, X. Zhuang, J. Ling, C. Lv, J. Wang, H. Song, J. Wang and C. Jin, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC00096C

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