Cancer-specific dual-factor cascade recognition fluorescent probe for imaging and tumor diagnosis

Ziqian Wang; Yitong Li; Hong Zhang; Yang Song; Zuguang Xue; Fangkui Yin; Lin Li; Maojun Jiang; Zhiyuan Hu; Zheming Wang; Yanxin Zhang; Zihan Wang; Siyao Wang; Ting Song; Zhichao Zhang

doi:10.1039/D4CC06634K

Cancer-specific dual-factor cascade recognition fluorescent probe for imaging and tumor diagnosis†

Ziqian Wang,^a Yitong Li,^b Hong Zhang,^a Yang Song,^c Zuguang Xue,^d Fangkui Yin,^b Lin Li,^b Maojun Jiang,^b Zhiyuan Hu,^e Zheming Wang,^b Yanxin Zhang,^e Zihan Wang,^b Siyao Wang,^b Ting Song*^a and Zhichao Zhang

*^a

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* Corresponding authors

^a Central Hospital of Dalian University of Technology, School of Pharmacy, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, China
E-mail: zczhang@dlut.edu.cn, songting@dlut.edu.cn

^b School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China

^c Department of Hematology, Central Hospital of Dalian University of Technology, Dalian University of Technology, Dalian, Liaoning, China

^d Department of Hematology, Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China

^e School of Life Science and Technology, Dalian University of Technology, Dalian, Liaoning, China

Abstract

Herein, we developed a dual-factor recognition activatable probe, S1-F, which accurately lights up Bcl-2 and GSH dual-overexpressed cancer tissue with a superior tumor-to-normal tissue (T/N) ratio, highlighting the potential for this probe to be used in the visual diagnosis and imaging-guided surgery of cancer.

Chemical Communications

Cancer-specific dual-factor cascade recognition fluorescent probe for imaging and tumor diagnosis†

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Cancer-specific dual-factor cascade recognition fluorescent probe for imaging and tumor diagnosis

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