Issue 18, 2024

Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Abstract

2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur as the sulfur source. Both aliphatic amines and aryl amines demonstrate good compatibility at room temperature, highlighting the broad functional group tolerance of this approach. Additionally, elemental selenium demonstrated reactivities comparable to those of elemental sulfur.

Graphical abstract: Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

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Article information

Article type
Paper
Submitted
16 Mar 2024
Accepted
18 Apr 2024
First published
18 Apr 2024

Org. Biomol. Chem., 2024,22, 3752-3760

Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

P. Huang, J. Fu, Y. Peng, J. Fan, L. Zhong, K. Tang and Y. Liu, Org. Biomol. Chem., 2024, 22, 3752 DOI: 10.1039/D4OB00432A

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