Issue 19, 2024

Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

Abstract

Plants from Moraceae are globally popular as they represent a valuable resource with wide applications in food, health-care products, and other fields. Prenylated flavonoids are important active components in Moraceae. These compounds share a flavonoid skeleton with prenylated side chain, mostly in the form of single or multiple isoprenyl substituents and benzodimethylfuran structures. So far, nearly 400 prenylated flavonoids have been found in Moraceae, especially a large number of Diels–Alder adducts, which are characteristic components of this family. Due to their distinctive structures, diverse pharmacological properties and interesting synthesis processes, these compounds have attracted considerable attention from scientists. Herein, we review the advances in the structural characteristics, bioactivities, structure–activity relationships, biosynthesis strategies and in vivo metabolism of prenylated flavonoids in Moraceae plants, aiming at strengthening research efforts and utilization toward the great untapped potential of these unique constituents in human health.

Graphical abstract: Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

Article information

Article type
Review Article
Submitted
06 Jun 2024
Accepted
19 Aug 2024
First published
22 Aug 2024

Food Funct., 2024,15, 9598-9631

Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

N. Li, W. Lu, H. Ren and Z. Chen, Food Funct., 2024, 15, 9598 DOI: 10.1039/D4FO02688H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements