A multi-functional nano-platform based on LiGa4.99O8:Cr0.01/IrO2 with near infrared-persistent luminescence, “afterglow” photodynamic and photo-thermal functions

Abstract

Multi-functionalised nano-platforms based on persistent-luminescence nanoparticles (PLNPs) have attracted considerable attention for biomedical applications owing to their lack of background noise and suitability for in vivo imaging without the need for in situ excitation. However, nano-platforms based on PLNPs for continuous photodynamic therapy (PDT) are currently lacking. Herein, we report a nano-platform (LiGa_4.99O₈:Cr_0.01/IrO₂, LGO:Cr/IrO₂) prepared using PLNPs (LiGa_4.99O₈:Cr_0.01, LGO:Cr) covalently bonded with iridium oxide nanoparticles (IrO₂ NPs), producing near-infrared (NIR) persistent luminescence, “afterglow” PDT and photo-thermal therapy (PTT) effects. The LGO:Cr/IrO₂ not only exhibits NIR-persistent luminescence at 719 nm and a PTT effect under 808 nm irradiation but also a continuous “afterglow” PDT effect without the need for in situ excitation owing to persistent energy transfer from LGO:Cr to the IrO₂ NPs, in turn generating reactive oxygen species (ROS). This multi-functional nano-platform is expected to further promote the application of PLNPs in tumour treatment.