Issue 17, 2024

Protein desulfurization and deselenization

Abstract

Methods enabling the dechalcogenation of thiols or selenols have been investigated and developed for a long time in fields of research as diverse as the study of prebiotic chemistry, the engineering of fuel processing techniques, the study of biomolecule structures and function or the chemical synthesis of biomolecules. The dechalcogenation of thiol or selenol amino acids is nowadays a particularly flourishing area of research for being a pillar of modern chemical protein synthesis, when used in combination with thiol or selenol-based chemoselective peptide ligation chemistries. This review offers a comprehensive and scholarly overview of the field, emphasizing emerging trends and providing a detailed and critical mechanistic discussion of the dechalcogenation methods developed so far. Taking advantage of recently published reports, it also clarifies some unexpected desulfurization reactions that were observed in the past and for which no explanation was provided at the time. Additionally, the review includes a discussion on principal desulfurization methods within the framework of newly introduced green chemistry metrics and toolkits, providing a well-rounded exploration of the subject.

Graphical abstract: Protein desulfurization and deselenization

Supplementary files

Article information

Article type
Tutorial Review
Submitted
29 Mar 2024
First published
16 Jul 2024

Chem. Soc. Rev., 2024,53, 8521-8545

Protein desulfurization and deselenization

V. Diemer, E. Roy, V. Agouridas and O. Melnyk, Chem. Soc. Rev., 2024, 53, 8521 DOI: 10.1039/D4CS00135D

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