Nickel-catalysed highly regioselective synthesis of β-acyl naphthalenes under reductive conditions

Abstract

Over the past decade, significant progress has been made in the direct C–H acylation of naphthalenes, occurring at the α or β-positions to yield valuable ketones through Friedel–Crafts acylation or transition-metal-catalysed carbonylative coupling reactions. Nevertheless, highly regioselective acylation of naphthalenes remains a formidable challenge. Herein, we developed a nickel-catalysed reductive ring-opening reaction of 7-oxabenzonorbornadienes with acyl chlorides as the electrophilic coupling partner, providing a new method for the exclusive preparation of β-acyl naphthalenes.