Issue 18, 2023

Injectable hydrogels of recombinant human collagen type III and chitosan with antibacterial and antioxidative activities for wound healing

Abstract

Designing a smart hydrogel to accelerate skin tissue regeneration at wound sites and restore the tissue function is highly desirable in clinical applications. In this study, a series of hydrogels with promising antioxidative and antibacterial traits based on recombinant human collagen type III (rhCol III), which is an emerging biomaterial, and chitosan (CS) were fabricated. The rhCol III-CS hydrogel could realize rapid gelation at wound locations and completely cover irregular wounds. Additionally, the hydrogel facilitated the proliferation and migration of cells and showed potent antibacterial efficacy against both strains, Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in vitro. Significantly, the rhCol III-CS2 hydrogel increased the deposition of collagen, thereby accelerating full-thickness wound healing. Collectively, this bioinspired hydrogel was a promising multifunctional dressing to reconfigure the damaged tissue without additional drugs, exogenous cytokines, or cells, providing an effective strategy for the repair and regeneration of skin wounds.

Graphical abstract: Injectable hydrogels of recombinant human collagen type III and chitosan with antibacterial and antioxidative activities for wound healing

  • This article is part of the themed collection: #MyFirstJMCB

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2023
Accepted
09 Mar 2023
First published
16 Mar 2023

J. Mater. Chem. B, 2023,11, 4131-4142

Injectable hydrogels of recombinant human collagen type III and chitosan with antibacterial and antioxidative activities for wound healing

L. Xiong, C. Zhou, L. Tong, X. Han, Y. Zou, Z. Dong, J. Liang, Y. Chen and Y. Fan, J. Mater. Chem. B, 2023, 11, 4131 DOI: 10.1039/D3TB00176H

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