Issue 10, 2023

ADDP facilitates C–S bond formation from sulfonyl chlorides with alcohols

Abstract

The formation of C–S bonds using cheap, stable and odorless sulfonyl chlorides and widely sourced and less toxic alcohols with the assistance of ADDP is reported. This method is suitable for a broad substrate scope and tolerates a broad range of functional groups. Additionally, our protocol provides a green and convenient methylating method utilizing methanol or methanol-d4 and allows trideuteromethylthiolation with sulfonyl chlorides. This method can be applied for the late-stage diversification of natural products and drug analogs.

Graphical abstract: ADDP facilitates C–S bond formation from sulfonyl chlorides with alcohols

Supplementary files

Article information

Article type
Paper
Submitted
24 Dec 2022
Accepted
15 Jan 2023
First published
09 Feb 2023

New J. Chem., 2023,47, 4746-4751

ADDP facilitates C–S bond formation from sulfonyl chlorides with alcohols

G. Sun, X. Liu, J. Li, J. Yang, J. Xie, X. Wen, H. Sun and Q. Xu, New J. Chem., 2023, 47, 4746 DOI: 10.1039/D2NJ06287A

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