Issue 11, 2023

Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc(0)

Abstract

The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith reaction is herein described. Harnessing the use of mechanochemical techniques to activate zinc(0), this, all under air and operationally simple protocol, allows the synthesis of a wide range of cyclopropane structures and scale up to enable gram-scale.

Graphical abstract: Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc(0)

Supplementary files

Article information

Article type
Paper
Submitted
23 Feb 2023
Accepted
26 Apr 2023
First published
15 May 2023
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2023,25, 4319-4325

Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc(0)

L. Pontini, J. A. Leitch and D. L. Browne, Green Chem., 2023, 25, 4319 DOI: 10.1039/D3GC00649B

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