Montmorillonite K10 catalyzed facile synthesis of N-substituted indoles from primary amines and Morita–Baylis–Hillman acetate of cyclohexenone

Abstract

The simultaneous construction of both rings of indole from primary amines and MBH acetate of cyclohexenone is established. This method employed montmorillonite K10 as a cheap catalyst and diethyl carbonate as a green solvent. The scope of the reaction was scouted, in which 37 N-substituted indoles including 1,1′-bisindole were obtained.