Issue 40, 2023
From the journal:

Dalton Transactions

Trinuclear rhenium(i)-based metallocages as anticancer agents towards human cervical cancer cells†

Moon Kedia,a   Sajmina Khatun,b   Upasana Phukon,a   Bhaskaran Shankar,c   Aravind Kumar Rengan ORCID logo *b  and  Malaichamy Sathiyendiran ORCID logo *a  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad-500 046, India
E-mail: msathi@uohyd.ac.in

b Department of Biomedical Engineering, Indian Institute of Technology, Kandi, Hyderabad-502 284, India
E-mail: aravind@bme.iith.ac.in

c Department of Chemistry, Thiagarajar College of Engineering, Madurai-625 015, India

Abstract

The first examples of spherical-shaped trinuclear rhenium(I) organometallic cages displaying cytotoxic, antimetastatic, antiproliferative and DNA-damaging behavior towards a human cervical (HeLa) cancer cell line are reported. The compact design of the metallocages facilitates their interactions with biosystems leading to comparable efficiency to that of the commonly used anticancer drug cisplatin.

Graphical abstract: Trinuclear rhenium(i)-based metallocages as anticancer agents towards human cervical cancer cells

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Article information

DOI
https://doi.org/10.1039/D3DT02535G
Article type
Communication
Submitted
05 Aug 2023
Accepted
27 Sep 2023
First published
27 Sep 2023

Dalton Trans., 2023,52, 14314-14318

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Trinuclear rhenium(I)-based metallocages as anticancer agents towards human cervical cancer cells

M. Kedia, S. Khatun, U. Phukon, B. Shankar, A. K. Rengan and M. Sathiyendiran, Dalton Trans., 2023, 52, 14314 DOI: 10.1039/D3DT02535G

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