Issue 3, 2023
From the journal:

CrystEngComm

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization†

Toshiyuki Sasaki, ORCID logo ‡*a   Takanori Nakane, ORCID logo ‡b   Akihiro Kawamoto, ORCID logo b   Tomohiro Nishizawa ORCID logo c  and  Genji Kurisu ORCID logo *bde  

* Corresponding authors

a Department of Materials System Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027, Japan
E-mail: tsasaki@yokohama-cu.ac.jp, t.devi.sasaki@gmail.com

b Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: gkurisu@protein.osaka-u.ac.jp

c Department of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

d Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka 560-0043, Japan

e Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible from solutions. Herein, we demonstrate the structure determination of a powdered mechano-distinctive co-crystal of 2-aminopyrimidine and succinic acid in a 2 : 1 molar ratio using microcrystal electron diffraction.

Graphical abstract: Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

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Article information

DOI
https://doi.org/10.1039/D2CE01522F
Article type
Communication
Submitted
10 Nov 2022
Accepted
23 Dec 2022
First published
24 Dec 2022
This article is Open Access
Creative Commons BY license

CrystEngComm, 2023,25, 352-356

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Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

T. Sasaki, T. Nakane, A. Kawamoto, T. Nishizawa and G. Kurisu, CrystEngComm, 2023, 25, 352 DOI: 10.1039/D2CE01522F

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