Issue 51, 2023

Dinuclear-gold-catalyzed cyclization of 1,7-enynes with alkyl bromides

Abstract

Dinuclear-gold-catalyzed radical difunctionalization of alkyl bromides with 1,7-enynes has been established via dehalogenation and 1,5-HAT processes. This protocol was used to construct, in a facile and efficient manner, a wide range of cyclopenta[c]quinolines bearing two quaternary carbon centers with good yields (28 examples, up to 84% yield). The good functional group compatibility and gram-scale preparation ability of the reaction proved its synthetic robustness.

Graphical abstract: Dinuclear-gold-catalyzed cyclization of 1,7-enynes with alkyl bromides

Supplementary files

Article information

Article type
Communication
Submitted
12 May 2023
Accepted
26 May 2023
First published
26 May 2023

Chem. Commun., 2023,59, 7943-7946

Dinuclear-gold-catalyzed cyclization of 1,7-enynes with alkyl bromides

J. Li, X. Zhai, C. Ji, W. Li and J. Xie, Chem. Commun., 2023, 59, 7943 DOI: 10.1039/D3CC02317F

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