Synthesis of acridinones via palladium-catalyzed reductive annulation of 2-nitrobenzaldehydes and resorcinols

Abstract

The catalytic conversion of biomass-derived feedstocks into functional molecules is of significance to synthetic organic chemistry. Herein, through a palladium-catalyzed reductive annulation reaction of resorcinols and 2-nitrobenzaldehydes, we present a new approach for the direct synthesis of acridinone derivatives, featuring operational simplicity, good substrate compatibility, and readily available feedstocks.