Issue 3, 2022
From the journal:

Organic Chemistry Frontiers

Palladium-catalyzed tandem hydrocarbonylative cycloaddition for expedient construction of bridged lactones†

Yongzheng Ding,a   Min Sia  and  Hanmin Huang ORCID logo *ab  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, Hefei 230026, P. R. China
E-mail: hanmin@ustc.edu.cn

b Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

Abstract

A palladium-catalyzed tandem carbonylative lactonization and cycloaddition reaction of 2-vinyl acetophenones with alkenes and CO has been established. This reaction enables an efficient conversion of the easily available alkenes to various bridged lactones through intermolecular cycloaddition. Furthermore, an intramolecular tandem hydrocarbonylative lactonization and cycloaddition reaction could also be established to access more complex bridged lactones by this strategy.

Graphical abstract: Palladium-catalyzed tandem hydrocarbonylative cycloaddition for expedient construction of bridged lactones

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Article information

DOI
https://doi.org/10.1039/D1QO01568K
Article type
Research Article
Submitted
18 Oct 2021
Accepted
11 Dec 2021
First published
13 Dec 2021

Org. Chem. Front., 2022,9, 715-719

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Palladium-catalyzed tandem hydrocarbonylative cycloaddition for expedient construction of bridged lactones

Y. Ding, M. Si and H. Huang, Org. Chem. Front., 2022, 9, 715 DOI: 10.1039/D1QO01568K

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