Electrochemical primary amination of imidazopyridines with azidotrimethylsilane under mild conditions

Abstract

A straightforward protocol involving electrochemical primary amination of imidazopyridines under mild conditions is described. This transformation utilizes TMSN₃ as the nitrogen source and a trace amount of H₂O as the hydrogen source. A wide range of imidazopyridines were found to be compatible, providing the corresponding C3-amino substituted imidazopyridines in moderate to good yields.