Issue 12, 2022

Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries

Abstract

Aromatic and heteroaromatic ketones bearing an α-methine proton can be deprotonated and mono-allylated in minutes in the complete absence of an organic solvent to arrive at the corresponding products in high isolated yields. Applications to synthetic targets including both MK-7 and MK-9, as well as coenzyme Q9 (CoQ9), utilizing this new technology are documented.

Graphical abstract: Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries

Supplementary files

Article information

Article type
Paper
Submitted
27 Feb 2022
Accepted
17 May 2022
First published
23 May 2022

Green Chem., 2022,24, 4909-4914

Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries

X. Li, A. B. Wood, N. R. Lee, F. Gallou and B. H. Lipshutz, Green Chem., 2022, 24, 4909 DOI: 10.1039/D2GC00776B

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