Issue 14, 2022

On-demand, in situ, generation of ammonium caroate (peroxymonosulfate) for the dihydroxylation of alkenes to vicinal diols

Abstract

Using the dihydroxylation of alkenes as a benchmark, the reactivities of fresh and aged solutions of (NH4)2S2O8 (electrochemically generated) were compared to commercially-procured peroxydisulfate and Oxone. The study revealed that peroxymonosulfate (Caro's acid, PMS) is the active oxidant in such reactions. Using complementary redox colorimetry and in situ IR spectroscopy, the decomposition of peroxydisulfate in an acidic solution into PMS and H2O2 can be quantified for the first time. The new insights enabled the design and implementation of both batch and flow processes to maximise the concentration of active PMS oxidant. The utility of these oxidants for organic synthesis is demonstrated by the dihydroxylation of eight styrenes and seven alkyl alkenes, where the ammonium PMS solutions performed better than Oxone (counterion effect). Last but not least, a chromatography-free method for isolating and purifying the water-soluble diol product was developed.

Graphical abstract: On-demand, in situ, generation of ammonium caroate (peroxymonosulfate) for the dihydroxylation of alkenes to vicinal diols

Supplementary files

Article information

Article type
Paper
Submitted
18 Feb 2022
Accepted
10 Jun 2022
First published
21 Jun 2022
This article is Open Access
Creative Commons BY license

Green Chem., 2022,24, 5570-5578

On-demand, in situ, generation of ammonium caroate (peroxymonosulfate) for the dihydroxylation of alkenes to vicinal diols

B. J. Deadman, S. Gian, V. E. Y. Lee, L. A. Adrio, K. Hellgardt and K. K. (. Hii, Green Chem., 2022, 24, 5570 DOI: 10.1039/D2GC00671E

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