Issue 10, 2022

Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice

Abstract

Constipation is one of the most common gastrointestinal tract symptoms. In this study, prebiotic sesame sugar (PSC) was prepared from isomalto-oligosaccharide, konjac glucomannan and sesame, and the relieving effect of PSC on constipation induced by loperamide was explored. The results showed that PSC treatment profoundly improved the defecation function and boosted intestinal motility. Moreover, PSC repaired gastrointestinal tissue injury and inflammation induced by constipation, which confirmed the effectiveness of PSC intervention in the treatment of constipation. The mechanism of PSC improving constipation might be that PSC improved the imbalance of gastrointestinal neurotransmitters and increased the content of short-chain fatty acids in feces. In conclusion, PSC dietotherapy could effectively alleviate the symptoms and lay a theoretical foundation for the development of an anti-constipation diet.

Graphical abstract: Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice

Supplementary files

Article information

Article type
Paper
Submitted
08 Jan 2022
Accepted
10 Apr 2022
First published
12 Apr 2022

Food Funct., 2022,13, 5690-5700

Evaluation of the effect of prebiotic sesame candies on loperamide-induced constipation in mice

P. Xia, X. Liu, T. Hou, F. Zhan, F. Geng, Z. Zhang and B. Li, Food Funct., 2022, 13, 5690 DOI: 10.1039/D2FO00067A

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