A novel cyclic dinuclear gold(I) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

Ahmed K. Abogosh; Meshal K. Alghanem; Saeed Ahmad; Abdullah Al-Asmari; Homood M. As Sobeai; Adam A. A. Sulaiman; Mohammed Fettouhi; Saheed A. Popoola; Ali Alhoshani; Anvarhusein A. Isab

doi:10.1039/D1DT03546K

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells†

Ahmed K. Abogosh,^a Meshal K. Alghanem,^a Saeed Ahmad,^b Abdullah Al-Asmari,^a Homood M. As Sobeai,^a Adam A. A. Sulaiman,

^c Mohammed Fettouhi,^cd Saheed A. Popoola,^e Ali Alhoshani

^a and Anvarhusein A. Isab

*^cf

Author affiliations

* Corresponding authors

^a Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

^b Department of Chemistry, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia

^c Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
E-mail: aisab@kfupm.edu.sa

^d Center for Refining and Advanced Chemicals, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

^e Department of Chemistry, Faculty of Science, Islamic University of Madinah, Saudi Arabia

^f Interdisciplinary Research Center for Advanced Materials, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

Abstract

A new dinuclear cyclic gold(I) complex [Au₂(DCyPA)₂](PF₆)₂, 1, based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopy, and X-ray crystallography. In the dinuclear complex cation [Au₂(DCyPA)₂]²⁺, the two gold(I) ions are bridged by the ligand bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) giving rise to a 16-membered ring centrosymmetric metallacycle. The cytotoxicity of the complex was evaluated against the triple-negative human breast cancer cells MDA-MB-231. In order to understand the mechanism of the cytotoxic behavior, a variety of assays, including Annexin V-FITC/Propidium iodide double staining, ROS production, and mitochondrial membrane potential and migration assays were carried out. The results indicated that complex 1 induced cytotoxicity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells.

Dalton Transactions

A novel cyclic dinuclear gold(i) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells†

Abstract

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A novel cyclic dinuclear gold(I) complex induces anticancer activity via an oxidative stress-mediated intrinsic apoptotic pathway in MDA-MB-231 cancer cells

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